In cases where the referees have requested well-defined changes to the manuscript that do not appear to require extensive further experiments, editors may request a revised manuscript that addresses the referees concerns. The revised version is normally sent back to some or all of the original referees for re-review. The decision letter will specify a deadline (typically two months), and revisions that are returned within this period will retain their original submission date.

In cases where the referees concerns are more wide-ranging, editors will normally reject the manuscript. If the editors feel the work is of potential interest to the journal, however, they may express interest in seeing a future resubmission. The resubmitted manuscript may be sent back to the original referees or to new referees, at the editors discretion. In such cases, revised manuscripts will not retain their earlier submission date.

In either case, the revised manuscript should be accompanied by a cover letter explaining how the manuscript has been changed, and a separate point-by-point response to referees comments. Ideally no more than two resubmissions will be considered for each manuscript, following which we will try to reach a final decision on publication.

An invited revision should be submitted via the revision link to the online submission system provided in the decision letter, not as a new manuscript.